Anti-ENO3 Products

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For Research Use Only. Not For Clinical Use.

Muscle biology and metabolic disease research take center stage with Creative Biolabs premium anti-ENO3 (Eno-β) recombinant antibodies. ENO3 is the muscle-specific isoform of the glycolytic enzyme enolase, and it is an essential regulator of muscle energy metabolism. It is also an important marker of muscle development and disease states. With our premium quality antibodies, you will have the most powerful tools for your studies on muscular dystrophies, myopathies, and metabolic muscle properties.

ENO3: The Muscle-Specific Glycolytic Enzyme

Enolase 3 (ENO3), also known as beta-enolase or Eno-β, is the muscle-specific isoform of the glycolytic enzyme enolase, a key enzyme in the conversion of glucose to pyruvate. It catalyzes the conversion of 2-phosphoglycerate (2-PG) to phosphoenolpyruvate (PEP), a high-energy intermediate, leading to the production of ATP. ENO3 is highly expressed in fast and slow skeletal muscle fibers, where it plays a critical role in supplying the high energy demand required for muscle contraction. Genetic mutations in ENO3 can lead to a rare glycogen storage disease (GSD XIII) that manifests as exercise intolerance and muscle breakdown (rhabdomyolysis).

Alternative Names

Enolase 3; Enolase 3 (Beta, Muscle); Muscle Enriched Enolase; Muscle-Specific Enolase; Skeletal Muscle Enolase; Beta-Enolase; EC 4.2.1.11

Background

This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme is found in skeletal muscle cells in the adult where it may play a role in muscle development and regeneration. A switch from alpha enolase to beta enolase occurs in muscle tissue during development in rodents. Mutations in this gene have be associated glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been described.

Anti-ENO3 rAb Products

Creative Biolabs' anti-ENO3 recombinant antibodies have been engineered with precision, rigorously validated for specificity to the beta-enolase isoform. We take great care to ensure that our antibodies do not cross-react with the neuronal (ENO2) or ubiquitously expressed (ENO1) isoforms, making them an ideal choice for muscle-specific research. Our rAbs have been optimized for IHC on muscle biopsy samples and Western Blot to provide you with a clean, specific signal and reliable, reproducible results.

Table 1. Featured anti-ENO3 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

To support the advanced research needs of the muscle biology field, Creative Biolabs leverages next generation production technologies. Our anti-ENO3 recombinant antibodies are expressed in systems that have been optimized to ensure that the antibodies recognize and bind to the native enzyme with high specificity, guaranteeing you a specific and active research tool.

Featured Anti-ENO3 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-ENO3 recombinant antibody production.

Fig.2 Gram-scale anti-ENO3 recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to delivering innovative and flexible solutions to power research. Our anti-ENO3 recombinant antibodies are available in multiple customizable modalities to accommodate a variety of experimental approaches. Whether you are using qPCR, IHC, ELISA, Western Blot, flow cytometry, or another application, we can engineer antibodies to suit your research needs. We are empowering researchers around the globe to study this important metabolic enzyme in muscle.

Fig.3 Full-length anti-ENO3 recombinant antibody production and modalities.

Decipher the complex regulation of muscle metabolism with Creative Biolabs' premium anti-ENO3 recombinant antibodies. Stringent validation and unparalleled performance define our portfolio and make our antibodies the ideal tools for your research into myopathies and muscle physiology. Trust us to power your next discovery. Contact our specialists today.