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    ENO3

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    For Research Use Only. Not For Clinical Use.


    This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme is found in skeletal muscle cells in the adult where it may play a role in muscle development and regeneration. A switch from alpha enolase to beta enolase occurs in muscle tissue during development in rodents. Mutations in this gene have be associated glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Jul 2010]
    Protein class

    Candidate cardiovascular disease genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets

    Predicted location

    Intracellular

    Single cell type specificity

    Group enriched (Cardiomyocytes, Skeletal myocytes)

    Immune cell specificity

    Low immune cell specificity

    Cell line specificity

    Cell line enhanced (HDLM-2, HeLa, HMC-1, RH-30, RPMI-8226)

    Interaction

    Mammalian enolase is composed of 3 isozyme subunits, alpha, beta and gamma, which can form homodimers or heterodimers which are cell-type and development-specific. Interacts with PNKD.

    Molecular function

    Lyase

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