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ERI1
Anti-ERI1 Recombinant Antibody Products
- Mouse Anti-NHP ERI1 Recombinant Antibody (clone OTI1B3) (VS-1024-XY189)
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- Species Reactivity: Human, Non-human primate, Rat
- Type: Mouse IgG2b
- Application: WB, IHC
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For Research Use Only. Not For Clinical Use.
Enables 3'-5' exonuclease activity. Predicted to be involved in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in cytoplasm and nucleolus.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Early spermatids)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Identified in a histone pre-mRNA complex, at least composed of ERI1, LSM11, SLBP, SNRPB, SYNCRIP and YBX1. Interacts in a cooperative manner with SLBP to the mature 3'-end of histone mRNAs (By similarity). Binds to 40S and 60S ribosomal subunits and to 80S assembled ribosomes. Found in a ternary complex with SLBP and the stem-loop structure of the 3'-end of histone mRNAs.
Molecular function
Exonuclease, Hydrolase, Nuclease, RNA-binding
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