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ESPL1

Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms.
Protein class

Enzymes

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Proximal enterocytes, Ionocytes, Squamous epithelial cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Low cell line specificity

Interaction

Interacts with PTTG1. Interacts with RAD21.

Molecular function

Hydrolase, Protease, Thiol protease

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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