Anti-F10 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is a world leader in cardiovascular research and drug discovery, specializing in our elite line of anti-F10 recombinant antibodies. As the final, and most potent enzyme of the coagulation cascade, Coagulation Factor X (F10) is one of the most desired targets for anticoagulant drug discovery programs. Our high-quality anti-F10 antibodies are powerful tools for better understanding the coagulation pathway, for the discovery of next-generation antithrombotic therapeutics, as well as for the development of reversal agents and diagnostic tests for these new anticoagulants.

F10: The Central Enzyme of the Coagulation Cascade

Coagulation Factor X (F10) is a vitamin K-dependent serine protease that sits at the central and rate-limiting step in blood coagulation. F10 is where both the intrinsic (F8/F9) and extrinsic (F7/TF) pathways converge and are both fully activated in order to subsequently activate Factor X (F10) to its enzymatic form, Factor Xa. Factor Xa then goes on to bind to its cofactor, Factor Va, and together they make up the so-called “prothrombinase complex”, which cleaves prothrombin to yield the massive burst of thrombin necessary to create a fibrin clot. Given its central role, F10a is the direct target of the “xaban” class of next-generation anticoagulants.

Alternative Names

FX; FXA; coagulation factor X; Stuart-Prower factor; factor X; factor Xa; prothrombinase

Background

This is an antibody binds to Factor Xa, it can be used for preventing and treating thromboembolic disorders.

Anti-F10 rAb Products

Our anti-F10 recombinant antibodies are designed to be high affinity and highly specific, and are extensively validated for the accurate detection of Factor X in plasma. Optimized for critical applications such as ELISA, Western Blot and functional assays to measure Factor Xa activity or inhibition, our rAbs are some of the most powerful tools available for cardiovascular drug discovery.

Table 1. Featured anti-F10 recombinant antibody products at Creative Biolabs.

Creative Quality Control

At Creative Biolabs we take our commitment to scientific excellence very seriously. The manufacturing of our anti-F10 recombinant antibodies is tightly controlled under a robust quality assurance program. All lots are tested for purity, binding kinetics and consistent performance in plasma-based assays, so that you can be confident you are receiving a reliable, high-quality reagent.

Fig.1 IHC analysis of anti-F10 antibody
(Cat# ZG-0659J, Creative Biolabs).

Customer Reviews

rAb Production

Creative Biolabs is committed to leveraging the latest production technologies to speed progress in drug discovery. Our anti-F10 recombinant antibodies are engineered for high affinity and specificity, making them excellent tools for the development of sensitive analytical assays as well as for the study of this critical enzyme.

Featured Anti-F10 Recombinant Antibody Production Platforms
Fig.2 Milligram-scale anti-F10 recombinant antibody production.

Fig.3 Gram-scale anti-F10 recombinant antibody production.

rAb Modalities

Creative Biolabs is dedicated to providing our customers with flexible and innovative tools to meet the ever-changing needs of the research community. Our anti-F10 recombinant antibodies are available in a range of customizable formats to suit your applications. Use our full-length IgGs for use in Western Blot or develop your own diagnostic assays with our matched pair antibodies.

Fig.4 Full-length anti-F10 recombinant antibody production and modalities.

F10-Targeted Drug Information

Table 2. Public drug targeting F10.

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

Power your next discovery in your anticoagulant drug discovery programs with Creative Biolabs’ superior anti-F10 recombinant antibodies. Defined by their high specificity and validation in plasma-based assays, our portfolio is the ideal set of tools for cardiovascular research. Place your trust in our expertise and we’ll help power your next breakthrough. Contact our specialists today.