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FLII
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- PE-A2/Human FLII (SLFPGKLEV) MHC Tetramer (MHC-LC1954)
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- Class: Class I
- Antigen: FLII
- Antigen Species: Human
- Peptide: SLFPGKLEV
- Conjugate: PE
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- PE-A*02:01/Human FLII (SLFPGKLEV) MHC Tetramer (MHC-LC1981)
-
- Class: Class I
- Antigen: FLII
- Antigen Species: Human
- Peptide: SLFPGKLEV
- Conjugate: PE
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For Research Use Only. Not For Clinical Use.
This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17.
Protein class
Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Pancreatic endocrine cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (A-431)
Interaction
Interacts with actin, ACTL6A, NCOA2, CARM1 and MYD88. Interacts with LRRFIP1 and LRRFIP2. Upon LPS stimulation, LRRFIP2 competes for MYD88-binding. LRRFIP1 constitutively blocks the interaction with MyD88, even in the absence of LPS. Interacts with the nuclear receptors ESR1 and THRB. Interacts with SGK3.
Molecular function
Actin-binding, Activator, Developmental protein
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