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GBP5
Anti-GBP5 Recombinant Antibody Products
- Mouse Anti-NHP GBP5 Recombinant Antibody (clone OTI5C9) (VS-1024-XY215)
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- Species Reactivity: Human, Non-human primate
- Type: Mouse IgG1
- Application: WB, IF, FC
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- Anti-GBP5 Immunohistochemistry Kit (VS-0325-XY905)
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- Species Reactivity: Human, Rat
- Target: GBP5
- Application: IHC
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For Research Use Only. Not For Clinical Use.
This gene belongs to the TRAFAC class dynamin-like GTPase superfamily. The encoded protein acts as an activator of NLRP3 inflammasome assembly and has a role in innate immunity and inflammation. Alternative splicing results in multiple transcript variants.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (NK-cells, T-cells, dendritic cells, Plasma cells)
Immune cell specificity
Immune cell enhanced (T-reg)
Cell line specificity
Cell line enhanced (EFO-21, NB-4, U-266/70, U-937)
Interaction
Homodimer (PubMed:21151871). Heterodimer with other family members, including GBP1, GBP2, GBP3 and GBP4 (PubMed:21151871). Dimerization is nucleotide-dependent; isoform 1 and isoform 2 form dimers when GTP-bound. GDP-bound isoform 2 is monomeric, while isoform 1 remains dimeric (PubMed:20180847). Dimerization regulates subcellular location. May also form tetramers (dimer of dimers) in the presence of GTP (PubMed:20180847). Interacts with NLRP3, possibly in its tetrameric form, and promotes PYCARD/ASC polymerization (PubMed:22461501).
Molecular function
Antimicrobial, Hydrolase
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