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GPER1
Loading...Anti-GPER1 Products
- Recombinant Anti-human GPER1 Antibody (MOB-415)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: WB, IP, FuncS
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- Recombinant Anti-human GPER1 Antibody Fab Fragment (MOB-415-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: WB, RIA, FuncS
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- Recombinant Anti-human GPER1 Antibody scFv Fragment (MOB-415-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: FC, IP, FuncS
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- Recombinant Human Anti-human GPER1 Antibody Fab Fragment (MHH-415-F(E))
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- Derivation: Human
- Species Reactivity: Human
- Type: Fab
- Application: Neut, WB, FuncS
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- Recombinant Human Anti-human GPER1 Antibody scFv Fragment (MHH-415-S(P))
-
- Derivation: Human
- Species Reactivity: Human
- Type: scFv
- Application: FC, Neut, Funcs
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum and a member of the G-protein coupled receptor 1 family. This receptor binds estrogen and activates multiple downstream signaling pathways, leading to stimulation of adenylate cyclase and an increase in cyclic AMP levels, while also promoting intracellular calcium mobilization and synthesis of phosphatidylinositol 3, 4, 5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. This receptor has been shown to play a role in diverse biological processes, including bone and nervous system development, metabolism, cognition, male fertility and uterine function. [provided by RefSeq, Aug 2017]
Protein class
G-protein coupled receptors, Transporters
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Hepatocytes, Kupffer cells, Distal enterocytes, Endothelial cells, Adipocytes)
Immune cell specificity
Group enriched (myeloid DC, classical monocyte, intermediate monocyte)
Cell line specificity
Cell line enhanced (AN3-CA, Daudi, fHDF/TERT166, Hep G2)
Interaction
Homodimer (Probable). Heterodimer; heterodimerizes with other G-protein-coupled receptor (GPCRs) like CRHR1, HTR1A and PAQR8. Interacts (via C-terminus tail motif) with DLG4 (via N-terminus tandem pair of PDZ domains); the interaction is direct and induces the increase of GPER1 protein levels residing at the plasma membrane surface in a estradiol-independent manner (By similarity). Interacts with RAMP3. Interacts with KRT7 and KRT8. Interacts with EGFR; the interaction increases after agonist-induced stimulation in cancer-associated fibroblasts (CAF). Interacts with EGFR and ESR1.
Molecular function
G-protein coupled receptor, Receptor, Transducer
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