GPR183

Formats

Anti-GPR183 Recombinant Antibody Products

Mouse Anti-GPR183 Recombinant Antibody (clone 42B1) (MOB-1913z)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: WB, ELISA, IF, IP
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For Research Use Only. Not For Clinical Use.

Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols. Binding of 7-alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses. Promotes activated B-cell localization in the outer follicle and interfollicular regions. Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses (By similarity). Signals constitutively through G(i)-alpha, but not through G(s)-alpha or G(q)-alpha. Signals constitutively also via MAPK1/3 (ERK1/2).

Protein class

G-protein coupled receptors

Predicted location

Membrane

Single cell type specificity

Group enriched (Langerhans cells, Macrophages)

Immune cell specificity

Immune cell enhanced (basophil)

Cell line specificity

Group enriched (HDLM-2, HL-60)

Interaction

Homodimer and heterodimer (PubMed:22913878). Heterodimerizes with CXCR5; leading to modulate the interaction between of CXCL13 and CXCR5 (PubMed:22913878).

Molecular function

G-protein coupled receptor, Receptor, Transducer

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