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GSDMB
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a member of the gasdermin-domain containing protein family. Other gasdermin-family genes are implicated in the regulation of apoptosis in epithelial cells, and are linked to cancer. Multiple transcript variants encoding different isoforms have been found for this gene. Additional variants have been described, but they are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to be protein-coding. [provided by RefSeq, Sep 2009]
Protein class
Transporters
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Proximal enterocytes, Gastric mucus-secreting cells, Paneth cells, Distal enterocytes, Intestinal goblet cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (SK-BR-3)
Interaction
[Gasdermin-B, N-terminal]: Homooligomer; homooligomeric ring-shaped pore complex containing 27-28 subunits when inserted in the membrane.
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