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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor.
Protein class
Cancer-related genes
Predicted location
Secreted
Single cell type specificity
Cell type enriched (Hofbauer cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (U-138 MG)
More Types Infomation