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IFNGR1
Loading...Anti-IFNGR1 ProductsBackground
Anti-IFNGR1 Products
- AbPlus™ Anti-IFNGR1 Magnetic Beads (GIR 208) (VS-0424-XY144)
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- Target: IFNGR1
- Target Species: Human
- Application: IP, Protein Purification
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- AbPlus™ Anti-IFNGR1 Magnetic Beads (VS-0724-YC530) (VS-0724-YC530)
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- Target: IFNGR1
- Target Species: Human
- Application: IP, Protein Purification
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- Species Reactivity: Human
- Target: IFNGR1
- Host Animal: Mouse
- Application: ELISA, FC, Neut, Cell-uptake
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- Anti-IFNGR1 Immunohistochemistry Kit (VS-0525-XY3415)
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- Species Reactivity: Human
- Target: IFNGR1
- Application: IHC
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- Anti-Mouse IFNGR1 Immunohistochemistry Kit (VS-0525-XY3416)
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- Species Reactivity: Mouse
- Target: IFNGR1
- Application: IHC
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More Infomation
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For Research Use Only. Not For Clinical Use.
Background
This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection.
Protein class
CD markers, Disease related genes, FDA approved drug targets, Human disease related genes
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Basal respiratory cells, Club cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Monomer (PubMed:9367779). Heterodimer with IFNGR2, to form the IFNG receptor complex (PubMed:7615558). Interacts with JAK1 (PubMed:7615558). Interacts (when phosphorylated) with STAT1 (PubMed:8156998). Interacts with SOCS1 (By similarity).
Molecular function
Receptor
More Types Infomation
Related Diseases
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