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IGF2R
Anti-IGF2R Recombinant Antibody Products
- Anti-IGF2R Immunohistochemistry Kit (VS-0325-XY1105)
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- Species Reactivity: Human, Mouse, Rat
- Target: IGF2R
- Application: IHC
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For Research Use Only. Not For Clinical Use.
IGF2R is a gene that encodes a receptor for the insulin-like growth factor 2 (IGF2), a protein involved in growth and development. The IGF2R receptor primarily functions by clearing IGF2 from the bloodstream, regulating its levels, and preventing overactivation of IGF2-mediated signaling. This is important for controlling cellular growth and differentiation, as dysregulation can lead to abnormal growth or contribute to cancer development. IGF2R is also involved in cellular processes such as endocytosis and is implicated in diseases like cancer, particularly in the regulation of tumor growth and metastasis.
Protein class
Cancer-related genes, CD markers, Plasma proteins, Transporters
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (NK-cells)
Immune cell specificity
Immune cell enhanced (neutrophil)
Cell line specificity
Low cell line specificity
Interaction
Binds HA-I and HA-II plasma membrane adapters (By similarity). Interacts with DPP4; the interaction is direct. Binds GGA1, GGA2 and GGA3. Interacts with the heterotrimeric retromer cargo-selective complex (CSC), formed by VPS26 (VPS26A or VPS26B), VPS29 and VPS35; which is involved in retrograde trafficking of the receptor from endosomes to the Golgi apparatus (Probable).
Molecular function
Receptor
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