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IL18R1
Loading...Anti-IL18R1 ProductsBackground
Anti-IL18R1 Products
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- Species Reactivity: Human, Monkey
- Type: Humanized antibody
- Application: FC, ELISA, Ibhibition
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- Anti-Human IL18R1 Recombinant Antibody (TAB-406CL)
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- Species Reactivity: Human
- Type: Antibody
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More Infomation
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For Research Use Only. Not For Clinical Use.
Background
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Protein class
CD markers, Enzymes, Plasma proteins
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (granulocytes, dendritic cells, NK-cells, Langerhans cells, T-cells)
Immune cell specificity
Immune cell enhanced (NK-cell)
Cell line specificity
Cell line enhanced (HDLM-2, HHSteC, U-937)
Interaction
Forms a ternary complex with IL18 and IL18RAP (PubMed:14528293, PubMed:25500532). Within this complex, IL18R1 is involved in ligand-binding and IL18RAP in signaling leading to NF-kappa-B and JNK activation (Probable). Interacts with SLC12A3 in peritoneal macrophages; this interaction is increased by IL18 treatment (By similarity).
Molecular function
Hydrolase, Receptor
More Types Infomation
Related Signaling Pathways
TNF Signaling Pathway