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IL1F10
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For Research Use Only. Not For Clinical Use.
Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. Reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. Increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS). Ligand for IL-36R/IL1RL2.
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Not detected
Immune cell specificity
Not detected in immune cells
Cell line specificity
Not detected
Interaction
Interacts with cargo receptor TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion.
Molecular function
Cytokine
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