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JAML
Loading...Anti-JAML Products
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- Derivation: Mouse
- Species Reactivity: Mouse
- Type: Mouse IgG
- Application: FACS, IP, SPR, FC, IF
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- Derivation: Mouse
- Species Reactivity: Mouse
- Type: Mouse Fab
- Application: FACS, IP, SPR, FC, IF
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- Derivation: Mouse
- Species Reactivity: Mouse
- Type: Mouse scFv
- Application: FACS, IP, SPR, FC, IF
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For Research Use Only. Not For Clinical Use.
Predicted to enable integrin binding activity and protein homodimerization activity. Involved in gamma-delta T cell activation and positive regulation of epithelial cell proliferation involved in wound healing. Located in plasma membrane. Orthologous to human JAML (junction adhesion molecule like).
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Group enriched (monocytes, Macrophages, dendritic cells, Kupffer cells, T-cells)
Immune cell specificity
Immune cell enhanced (eosinophil)
Cell line specificity
Cell line enriched (HMC-1)
Interaction
Homodimer; active form in leukocyte-endothelial cell adhesion. Interacts (homodimeric form) with CXADR. Interacts (via cytoplasmic domain) with the PI3 kinase; upon CXADR-binding. Interacts with ITGA4 and ITGB1; integrin alpha-4/beta-1 may regulate leukocyte to endothelial cells adhesion by controlling JAML homodimerization.
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