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KCNA5

Engineered Antibody
KCNA5 (Potassium Voltage-Gated Channel Subfamily A Member 5) is a Protein Coding gene. Potassium channels represent the most complex class of voltage-gated ino channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Diseases associated with KCNA5 include Atrial Fibrillation, Familial, 7 and Familial Atrial Fibrillation.
Protein class

Disease related genes, FDA approved drug targets, Human disease related genes, Transporters, Voltage-gated ion channels

Predicted location

Membrane

Single cell type specificity

Cell type enriched (Bipolar cells)

Immune cell specificity

Immune cell enriched (plasmacytoid DC)

Cell line specificity

Cell line enriched (NTERA-2)

Interaction

Homotetramer and heterotetramer of potassium channel proteins. Interacts with DLG1, which enhances channel currents. Forms a ternary complex with DLG1 and CAV3 (By similarity). Interacts with KCNAB1 (PubMed:12130714). Interacts with UBE2I (PubMed:17261810).

Molecular function

Ion channel, Potassium channel, Voltage-gated channel

More Types Infomation

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