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LAMB3
Loading...Anti-LAMB3 Products
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB
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- Anti-LAMB3 Immunohistochemistry Kit (VS-0525-XY3930)
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- Species Reactivity: Human
- Target: LAMB3
- Application: IHC
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- Anti-Rat LAMB3 Immunohistochemistry Kit (VS-0525-XY3931)
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- Species Reactivity: Human, Rat
- Target: LAMB3
- Application: IHC
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For Research Use Only. Not For Clinical Use.
The product encoded by this gene is a laminin that belongs to a family of basement membrane proteins. This protein is a beta subunit laminin, which together with an alpha and a gamma subunit, forms laminin-5. Mutations in this gene cause epidermolysis bullosa junctional Herlitz type, and generalized atrophic benign epidermolysis bullosa, diseases that are characterized by blistering of the skin. Multiple alternatively spliced transcript variants that encode the same protein have been found for this gene.
Protein class
Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Pancreatic endocrine cells, Basal respiratory cells, Urothelial cells, Basal prostatic cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (CAPAN-2, HaCaT, HBEC3-KT, hTCEpi)
Interaction
Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Beta-3 is a subunit of laminin-5 (laminin-332 or epiligrin/kalinin/nicein). Interacts with ECM1.
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