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LGALS3BP

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions.
Protein class

Cancer-related genes, Plasma proteins

Predicted location

Secreted

Single cell type specificity

Cell type enhanced (Proximal enterocytes, Distal enterocytes, Paneth cells)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (CAPAN-2, SK-BR-3)

Interaction

Homodimers and homomultimers. The multimers form ring-like structures with a diameter of 30-40 nm. Binds LGALS1 and LGALS3. Binds ITGB1, COL4A1, COL5A1, COL6A1, FN1 and NID. Interacts with the gamma-tubulin ring complex (gamma-TuRC), composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6 (PubMed:29162697). The unglycosylated form interacts with PDE4DIP isoform 13/MMG8/SMYLE; this interaction may connect a pericentrosomal complex, made of AKAP9, CDK5RAP2, EB1/MAPRE1 and PDE4DIP, to the gamma-tubulin ring complex (gamma-TuRC) to promote microtubule assembly and acetylation (PubMed:29162697).

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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