LGI1

Leucine-rich glioma inactivation 1, also known as LGI1, is a protein encoded by the LGI1 gene in humans. It may be a metastasis inhibitor.

Due to the translocation of the glioblastoma cell line, the leucine-rich glioma inactivation-1 gene was rearranged. The protein contains a hydrophobic fragment, representing a putative transmembrane domain, with the amino terminus located outside the cell. It also contains leucine-rich repeat sequences and cysteine-rich conserved flanking sequences. This gene is mainly expressed in nerve tissues, its expression is reduced in low-grade brain tumors, and it is significantly reduced or not expressed in malignant gliomas.