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For Research Use Only. Not For Clinical Use.


May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus.
Protein class

Cancer-related genes, Disease related genes, Plasma proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Late spermatids, Early spermatids)

Immune cell specificity

Immune cell enhanced (neutrophil)

Cell line specificity

Cell line enhanced (Daudi, EFO-21, U-698)

Interaction

Interacts with VASP, with PDZ domains of SCRIB and with ACTN1/alpha-actinin.

Molecular function

Activator

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