MERTK

AbPlus Recombinant Antibody Products Functional Antibody Products Formats

Anti-MERTK Recombinant Antibody Products

Recombinant Mouse Anti-MERTK Antibody (NEUT-1725CQ) (NEUT-1725CQ)
- Species Reactivity: Human
- Type: IgG
- Application: BL, WB, IP, IHC-P
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For Research Use Only. Not For Clinical Use.

This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).

Protein class

Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Astrocytes, Microglial cells, Kupffer cells, Macrophages)

Immune cell specificity

Group enriched (intermediate monocyte, non-classical monocyte)

Cell line specificity

Cell line enhanced (CACO-2, Hep G2, HUVEC TERT2, RT4)

Interaction

Interacts (upon activation) with TNK2; stimulates TNK2 autophosphorylation. Interacts (via N-terminus) with extracellular ligands LGALS3, TUB, TULP1 and GAS6 (By similarity). Interacts with VAV1 in a phosphotyrosine-independent manner. Interacts with TIMD4; this interaction enhances TIMD4-mediated efferocytosis (PubMed:32640697).

Molecular function

Kinase, Receptor, Transferase, Tyrosine-protein kinase

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