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MICAL1
Loading...Anti-MICAL1 Products
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- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: IgG
- Application: WB, IP
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- Anti-MICAL1 Immunohistochemistry Kit (VS-0525-XY4391)
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- Species Reactivity: Human
- Target: MICAL1
- Application: IHC
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For Research Use Only. Not For Clinical Use.
This gene encodes an enzyme that oxidizes methionine residues on actin, thereby promoting depolymerization of actin filaments. This protein interacts with and regulates signalling by NEDD9/CAS-L (neural precursor cell expressed, developmentally down-regulated 9). Alternative splicing results in multiple transcript variants.
Protein class
Enzymes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Gastric mucus-secreting cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (THP-1)
Interaction
Interacts with STK38 and STK38L (By similarity). Interacts with RAB1B, RAB8A, RAB10, RAB13 and RAB15 (in their GTP-bound forms); binding to RAB1B is of low affinity compared to other Rab proteins; at least in case of RAB8A and RAB10 can bind 2 molecules of the Rab proteins simultaneously; ternary complex formation of RAB8A, RAB13 and MICAL1 is possible. Associates with the SH3 domain of NEDD9. Interacts with VIM and PLXNA3. Interacts with RAB1B.
Molecular function
Actin-binding, Monooxygenase, Oxidoreductase
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