MYO7A

AbPlus Recombinant Antibody Products

Anti-MYO7A Recombinant Antibody Products

Hi-Affi™ Recombinant Rabbit Anti-MYO7A Monoclonal Antibody (DS2351AB) (MOR-2351)
- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: IgG
- Application: WB, ICC/IF, FC
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For Research Use Only. Not For Clinical Use.

This gene is a member of the myosin gene family. Myosins are mechanochemical proteins characterized by the presence of a motor domain, an actin-binding domain, a neck domain that interacts with other proteins, and a tail domain that serves as an anchor. This gene encodes an unconventional myosin with a very short tail. Defects in this gene are associated with the mouse shaker-1 phenotype and the human Usher syndrome 1B which are characterized by deafness, reduced vestibular function, and (in human) retinal degeneration. Alternative splicing results in multiple transcript variants.

Protein class

Disease related genes, Human disease related genes

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Cone photoreceptor cells, Cytotrophoblasts, Rod photoreceptor cells, Hofbauer cells, Kupffer cells)

Immune cell specificity

Immune cell enhanced (classical monocyte, intermediate monocyte)

Cell line specificity

Cell line enhanced (BEWO, CACO-2, RH-30, RPMI-8226, SK-BR-3, U-937)

Interaction

Might homodimerize in a two headed molecule through the formation of a coiled-coil rod (By similarity). Identified in a complex with USH1C and USH1G (PubMed:21709241). Interacts with MYRIP (PubMed:11964381). Interacts with RPE65 (PubMed:21493626). Interacts with CIB2 (PubMed:23023331). May interact with CALM (PubMed:15300860). Interacts with WHRN (By similarity). Interacts with PLEKHB1 (via PH domain) (By similarity). Interacts with PCDH15 (By similarity). Interacts with TWF2 (By similarity). Interacts with USH1G (By similarity). Interacts with MYH9 (By similarity). Interacts (via MyTH4-FERM domains) with cytoplasmic regions of ADGRV1 and USH2A. Interacts with PDZD7 (via MyTH4-FERM domains) (By similarity).

Molecular function

Actin-binding, Calmodulin-binding, Motor protein, Myosin

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