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Methotrexate
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- Recombinant Anti-MTX Antibody (MOB-680)
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- Derivation: Mouse
- Type: IgG
- Application: ELISA, WB, FuncS
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- Mouse Anti-MTX Recombinant Antibody (clone AB119) (HPAB-0725-FY)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA
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- Recombinant Human Anti-MTX Antibody (MHH-680)
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- Derivation: Human
- Type: IgG
- Application: ELISA, IP, FuncS
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- Mouse Anti-MTX Recombinant Antibody (HPAB-AP396-YC) (HPAB-AP396-YC)
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- Type: Mouse IgG
- Application: ECL
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- Mouse Anti-MTX Recombinant Antibody (HPAB-AP397-YC) (HPAB-AP397-YC)
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- Type: Mouse IgG
- Application: ECL
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- Mouse Anti-MTX Recombinant Antibody (HPAB-AP398-YC) (HPAB-AP398-YC)
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- Type: Mouse IgG
- Application: ECL
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- Mouse Anti-MTX Recombinant Antibody; scFv Fragment (HPAB-AP396-YC-S(P)) (HPAB-AP396-YC-S(P))
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- Type: Mouse scFv
- Application: ECL
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- Mouse Anti-MTX Recombinant Antibody; scFv Fragment (HPAB-AP397-YC-S(P)) (HPAB-AP397-YC-S(P))
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- Type: Mouse scFv
- Application: ECL
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- Recombinant Human Anti-MTX Antibody Fab Fragment (MHH-680-F(E))
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- Derivation: Human
- Type: Fab
- Application: IP, Neut, FuncS
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- Recombinant Human Anti-MTX Antibody scFv Fragment (MHH-680-S(P))
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- Derivation: Human
- Type: scFv
- Application: ELISA, WB, FuncS
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- Mouse Anti-MTX Recombinant Antibody; scFv Fragment (HPAB-AP398-YC-S(P)) (HPAB-AP398-YC-S(P))
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- Type: Mouse scFv
- Application: ECL
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- Mouse Anti-MTX Recombinant Antibody; Fab Fragment (HPAB-AP396-YC-F(E)) (HPAB-AP396-YC-F(E))
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- Type: Mouse Fab
- Application: ECL
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- Mouse Anti-MTX Recombinant Antibody; Fab Fragment (HPAB-AP397-YC-F(E)) (HPAB-AP397-YC-F(E))
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- Type: Mouse Fab
- Application: ECL
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- Mouse Anti-MTX Recombinant Antibody; Fab Fragment (HPAB-AP398-YC-F(E)) (HPAB-AP398-YC-F(E))
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- Type: Mouse Fab
- Application: ECL
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- Mouse Anti-MTX Recombinant Antibody (clone AB119); Fab Fragment (HPAB-0725-FY-S(P))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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- Mouse Anti-MTX Recombinant Antibody (clone AB119); scFv Fragment (HPAB-0725-FY-F(E))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
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- Camelid Anti-Methotrexate Recombinant Antibody (HPAB-0734-YJ-VHH) (HPAB-0734-YJ-VHH)
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- Derivation: Phage display library
- Species Reactivity: Chemical
- Type: Camelid VHH
- Application: ELISA
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- Camelid Anti-Methotrexate Recombinant Antibody (HPAB-0735-YJ-VHH) (HPAB-0735-YJ-VHH)
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- Derivation: Phage display library
- Species Reactivity: Chemical
- Type: Camelid VHH
- Application: ELISA
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- Recombinant Anti-MTX Antibody Fab Fragment (MOB-680-F(E))
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- Derivation: Mouse
- Type: Fab
- Application: WB, IP, FuncS
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- Recombinant Anti-MTX Antibody scFv Fragment (MOB-680-S(P))
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- Derivation: Mouse
- Type: scFv
- Application: ELISA, WB, IF, FuncS
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- DrugMonitor™ Anti-Methotrexate Antibody (VS-1124-YC648) (VS-1124-YC648)
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- Specificity: Methotrexate
- Species Reactivity: Non-species dependent
- Type: Rabbit IgG
- Application: ELISA, PK/PD, ADA control
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- DrugMonitor™ Mouse Anti-Methotrexate Antibody (VS-0125-YC1362) (VS-0125-YC1362)
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- Specificity: Methotrexate
- Type: Mouse IgG
- Application: ELISA, Lateral Flow
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For Research Use Only. Not For Clinical Use.
Background
Methotrexate (MTX) is a clinically important antifolate drug, which competitively inhibits dihydrofolate reductase (DHFR), thereby impairing folate production. Folate is necessary for the de novo synthesis of thymidine, required for DNA synthesis. Folate is also required for purine base synthesis of DNA, RNA, thymidylates, and proteins. Thus, methotrexate impairs synthesis of thymidine and other metabolites crucial for cell proliferation.
Methotrexate, an antineoplastic agent, is used to treat a range of cancers as well as severe psoriasis, severe rheumatoid arthritis, and juvenile rheumatoid arthritis.