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NF1
Loading...Anti-NF1 Products
- Mouse Anti-NF1 Recombinant Antibody (clone 36C6) (MOB-3982z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, IP, IF, IHC, ELISA
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- Anti-Mouse NF1 Immunohistochemistry Kit (VS-0525-XY4804)
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- Species Reactivity: Human, Mouse, Rat, Porcine
- Target: NF1
- Application: IHC
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- Anti-NF1 Immunohistochemistry Kit (VS-0325-XY1485)
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- Species Reactivity: Human, Mouse, Rat
- Target: NF1
- Application: IHC
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For Research Use Only. Not For Clinical Use.
This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene.
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, RAS pathway related proteins
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Oligodendrocyte precursor cells, Inhibitory neurons, Excitatory neurons, Oligodendrocytes, Astrocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Interacts with HTR6 (PubMed:23027611).
Molecular function
GTPase activation
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