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NKD1

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For Research Use Only. Not For Clinical Use.


Background

In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.
Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Oligodendrocyte precursor cells, Microglial cells, Oligodendrocytes, Smooth muscle cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (AF22, CACO-2, Hep G2)

Interaction

Interacts with DVL1, DVL2, DVL3 and PPP2R3A.

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