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NKD1
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For Research Use Only. Not For Clinical Use.
Background
In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Oligodendrocyte precursor cells, Microglial cells, Oligodendrocytes, Smooth muscle cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (AF22, CACO-2, Hep G2)
Interaction
Interacts with DVL1, DVL2, DVL3 and PPP2R3A.
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