+ Filter
Loading...
NPPB
Loading...Anti-NPPB ProductsBackground
Anti-NPPB Products
CompareCan't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag
More Infomation
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
For Research Use Only. Not For Clinical Use.
Background
NPPB is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of NPPB in the bloodstream is indicative of heart failure. NPPB also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in NPPB have been associated with postmenopausal osteoporosis.
Protein class
Candidate cardiovascular disease genes, Plasma proteins
Predicted location
Secreted
Single cell type specificity
Cell type enhanced (Cardiomyocytes, Ductal cells, Pancreatic endocrine cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (BEWO, CACO-2, SuSa)
Molecular function
Hormone, Vasoactive, Vasodilator
More Types Infomation