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NR1I2

This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.
Protein class

FDA approved drug targets, Nuclear receptors, Plasma proteins, Transcription factors, Transporters

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Proximal enterocytes, Hepatocytes, Distal enterocytes, Paneth cells, Undifferentiated cells)

Immune cell specificity

Immune cell enriched (NK-cell)

Cell line specificity

Cell line enriched (Hep G2)

Interaction

Heterodimer with RXR. Interacts with NCOA1. Interacts (via domain NR LBD) with CRY1 and CRY2 in a ligand-dependent manner (By similarity).

Molecular function

Activator, DNA-binding, Receptor

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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