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NR5A1
Anti-NR5A1 Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a monomer. Defects in this gene are a cause of XY sex reversal with or without adrenal failure as well as adrenocortical insufficiency without ovarian defect.
Protein class
Disease related genes, Human disease related genes, Nuclear receptors, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Group enriched (Theca cells, Granulosa cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (HEL, Hep G2, K-562)
Interaction
Binds DNA as a monomer. Interacts with NR0B2 and PPARGC1A (By similarity). Part of a complex consisting of SFPQ, NONO and NR5A1. Interacts with NCOA2. Interacts with DGKQ and CDK7. Binds to and activated by HIPK3.
Molecular function
Activator, DNA-binding, Receptor
More Types Infomation
Related Diseases
Cushing Syndrome