Nos3 (pSer1177)

Enables nitric-oxide synthase activity and scaffold protein binding activity. Involved in several processes, including heart development; negative regulation of muscle hyperplasia; and smooth muscle hyperplasia. Acts upstream of with a positive effect on positive regulation of gene expression. Acts upstream of or within several processes, including lipopolysaccharide-mediated signaling pathway; nitric oxide biosynthetic process; and regulation of metal ion transport. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; hemolymphoid system gland; and nervous system. Used to study aortic valve disease; essential hypertension; persistent fetal circulation syndrome; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including artery disease; eye disease; leukemia; reproductive organ cancer; and vasculitis.