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PAPPA2
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For Research Use Only. Not For Clinical Use.
This gene encodes a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
Protein class
Enzymes
Predicted location
Membrane, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Enteroendocrine cells, Syncytiotrophoblasts, Extravillous trophoblasts, Muller glia cells, Oligodendrocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (U-87 MG)
Interaction
Monomer.
Molecular function
Hydrolase, Metalloprotease, Protease
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