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PARL
Anti-PARL Recombinant Antibody Products
- Mouse Anti-PARL Monoclonal Antibody (clone 8C4B2) (VS7-0425-WR560)
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- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: WB, ELISA
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More Infomation
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For Research Use Only. Not For Clinical Use.
This gene encodes a member of the rhomboid family of intramembrane serine proteases that is localized to the inner mitochondrial membrane. The encoded protein regulates mitochondrial remodeling and apoptosis through regulated substrate proteolysis. Proteolytic processing of the encoded protein results in the release of a small peptide, P-beta, which may transit to the nucleus. Mutations in this gene may be associated with Parkinson's disease. [provided by RefSeq, May 2016]
Protein class
Enzymes, Transporters
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Interacts with PSEN1 and PSEN2. Binds OPA1.
Molecular function
Hydrolase, Protease, Serine protease
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