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PDE1C
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For Research Use Only. Not For Clinical Use.
Background
Cyclic nucleotide phosphodiesterases (PDEs) catalyze hydrolysis of the cyclic nucleotides cAMP and cGMP to the corresponding nucleoside 5-prime-monophosphates. Mammalian PDEs have been classified into several families based on their biochemical properties. Members of the PDE1 family, such as PDE1C, are calmodulin (see MIM 114180)-dependent PDEs (CaM-PDEs) that are stimulated by a calcium-calmodulin complex (Repaske et al., 1992 [PubMed 1326532]).
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enriched (Oligodendrocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (BJ, fHDF/TERT166, hTERT-RPE1, U-251 MG, WM-115)
Interaction
Homodimer.
Molecular function
Calmodulin-binding, Hydrolase
More Types Infomation
Related Signaling Pathways
cAMP Signaling Pathway