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PHF1
Anti-PHF1 Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
This gene encodes a Polycomb group protein. The protein is a component of a histone H3 lysine-27 (H3K27)-specific methyltransferase complex, and functions in transcriptional repression of homeotic genes. The protein is also recruited to double-strand breaks, and reduced protein levels results in X-ray sensitivity and increased homologous recombination. Multiple transcript variants encoding different isoforms have been found for this gene.
Protein class
Disease related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Early spermatids)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (GAMG, HMC-1)
Interaction
Interacts with CHMP1 (By similarity). Associated component of the PRC2 complex. Interacts with p53/TP53.
Molecular function
Chromatin regulator, Repressor
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