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POLE
Anti-POLE Recombinant Antibody Products
- Anti-POLE Immunohistochemistry Kit (VS-0325-XY1691)
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- Species Reactivity: Human
- Target: POLE
- Application: IHC
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For Research Use Only. Not For Clinical Use.
This gene encodes the catalytic subunit of DNA polymerase epsilon. The enzyme is involved in DNA repair and chromosomal DNA replication. Mutations in this gene have been associated with colorectal cancer 12 and facial dysmorphism, immunodeficiency, livedo, and short stature.
Protein class
Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Spermatocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Low cell line specificity
Interaction
Component of the DNA polymerase epsilon complex consisting of four subunits: the catalytic subunit POLE and the accessory subunits POLE2, POLE3 and POLE4. Interacts with RAD17 and TOPBP1.
Molecular function
DNA-binding, DNA-directed DNA polymerase, Hydrolase, Nucleotidyltransferase, Transferase
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