PRKRA

AbPlus Recombinant Antibody Products Formats

Anti-PRKRA Recombinant Antibody Products

Anti-PRKRA Immunohistochemistry Kit (VS-0325-XY1759)
- Species Reactivity: Human, Mouse, Rat
- Target: PRKRA
- Application: IHC
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For Research Use Only. Not For Clinical Use.

This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection.

Protein class

Disease related genes, Human disease related genes

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Late spermatids)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Homodimer. Interacts with EIF2AK2/PKR through its DRBM domains. Interacts with DICER1, AGO2 and TARBP2. Also able to interact with dsRNA. Interacts with UBC9 (By similarity). Forms a complex with UBC9 and p53/TP53 (By similarity). Interacts with DUS2L (via DRBM domain). Interacts with DDX58. (Microbial infection) Interacts with ebolavirus protein VP35; this interaction inhibits the interaction between DDX58 and PRKRA. In addition, this interaction disrupts the interaction between VP35 and the viral polymerase L. So the VP35-PRKRA interaction plays a critical role in determining the outcome of ebolavirus infection (PubMed:23870315). The interaction PRKRA-VP35 also prevents PRKRA binding to DICER1 and thus allows the virus to counteract host RNA silencing (PubMed:21228243).

Molecular function

RNA-binding

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