PTK6

AbPlus Formats

Anti-PTK6 Recombinant Antibody Products

Anti-PTK6 Immunohistochemistry Kit (VS-0325-XY1819)
- Species Reactivity: Human, Mouse, Rat
- Target: PTK6
- Application: IHC
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For Research Use Only. Not For Clinical Use.

The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue.

Protein class

Cancer-related genes, Enzymes, Metabolic proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Distal enterocytes, Paneth cells, Proximal enterocytes, Gastric mucus-secreting cells, Squamous epithelial cells, Intestinal goblet cells)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (A-431, CAPAN-2, HaCaT, hTCEpi, OE19, RT4, T-47d)

Interaction

Interacts with GAP-A. p65 (By similarity). Interacts (via SH3 and SH2 domains) with KHDRBS1. Interacts (via SH3 and SH2 domains) with phosphorylated IRS4. Interacts with ADAM15. Interacts (via SH3 domain) with SFPQ. Interacts with EGFR and ERBB2. Interacts with STAP2. Interacts with PNX. Interacts with SFPQ. Interacts with PTK/ATK. Interacts with CTNNB1.

Molecular function

Kinase, Transferase, Tyrosine-protein kinase

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