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RAD21
Loading...Anti-RAD21 Products
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgM, κ
- Application: WB, IP, IF, ELISA
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- Rabbit Anti-RAD21 Recombinant Antibody (VS3-FY2858) (VS3-FY2858)
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- Species Reactivity: Human, Hamster
- Type: Rabbit IgG
- Application: WB, IHC, ICC
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- Mouse Anti-NHP RAD21 Recombinant Antibody (clone 1B6D1) (VS-1024-XY429)
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- Species Reactivity: Human, Non-human primate, Rat
- Type: Mouse IgG1
- Application: WB, IHC, ELISA
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- Anti-RAD21 Immunohistochemistry Kit (VS-0325-XY1862)
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- Species Reactivity: Human, Mouse, Rat
- Target: RAD21
- Application: IHC
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA double-strand breaks, as well as in chromatid cohesion during mitosis. This protein is a nuclear phospho-protein, which becomes hyperphosphorylated in cell cycle M phase. The highly regulated association of this protein with mitotic chromatin specifically at the centromere region suggests its role in sister chromatid cohesion in mitotic cells.
Protein class
Cancer-related genes, Disease related genes, Human disease related genes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Late spermatids)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Component of the cohesin complex, which consists of an SMC1A/B and SMC3 heterodimer core and 2 non-Smc subunits RAD21 and STAG1/SA1, STAG2/SA2 or STAG3/SA3 (PubMed:10931856, PubMed:11590136, PubMed:22628566, PubMed:25575569). Interacts (via N-terminus) with SMC1A; the interaction is direct (PubMed:12198550). The cohesin complex interacts with NUMA1 (PubMed:11590136). The cohesin complex also interacts with CDCA5, PDS5A and PDS5B; this interaction might regulate the ability of the cohesin complex to mediate sister chromatid cohesion (PubMed:15837422). The interaction with PDS5B is direct and is stimulated by STAG1/SA1 (PubMed:19696148). The cohesin complex interacts with the cohesin loading complex subunits NIPBL/Scc2 (via HEAT repeats) and MAU2/Scc4 (PubMed:22628566). The cohesin complex interacts with DDX11/ChIR1 (PubMed:17105772). Directly interacts with WAPL; this interaction is stimulated by STAG1/SA1 (PubMed:19696148). Interacts with the ISWI chromatin remodeling complex component SMARCA5; the interaction is direct (PubMed:12198550). Interacts with the NuRD complex component CHD4; the interaction is direct (PubMed:12198550).
Molecular function
Activator, Developmental protein, Repressor
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