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RANBP1

Anti-RANBP1 Products

Mouse Anti-RANBP1 Recombinant Antibody (clone 39G12) (MOB-3448z)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, IP, IF, ELISA
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Anti-RANBP1 Immunohistochemistry Kit (VS-0325-XY1872)
- Species Reactivity: Human, Mouse, Rat
- Target: RANBP1
- Application: IHC
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Hi-Affi™ Recombinant Rabbit Anti-RANBP1 Monoclonal Antibody (DS2993AB) (MOR-2993)
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB
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For Research Use Only. Not For Clinical Use.

Background

This gene encodes a protein that forms a complex with Ras-related nuclear protein (Ran) and metabolizes guanoside triphosphate (GTP). This complex participates in the regulation of the cell cycle by controlling transport of proteins and nucleic acids into the nucleus. There are multiple pseudogenes for this gene on chromosomes 9, 12, 17, and X. Alternative splicing results in multiple transcript variants.

Protein class

Plasma proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Extravillous trophoblasts)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (K-562)

Interaction

Interacts with RAN (via C-terminus of GTP-bound form) but not with GDP-bound RAN (PubMed:7882974, PubMed:7891706, PubMed:8896452). Identified in a complex composed of RAN, RANGAP1 and RANBP1 (PubMed:16428860, PubMed:11832950). Identified in a complex that contains TNPO1, RAN and RANBP1. Identified in a complex that contains CSE1L, KPNA2, RAN and RANBP1 (By similarity). Identified in a complex with nucleotide-free RAN and RCC1 (PubMed:7882974, PubMed:7616957).

Molecular function

GTPase activation

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