RANBP3

Recombinant Antibody Products Formats

Anti-RANBP3 Recombinant Antibody Products

Hi-Affi™ Recombinant Rabbit Anti-RANBP3 Monoclonal Antibody (DS2994AB) (MOR-2994)
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, IHC, ICC, IP, FC
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Hi-Affi™ Recombinant Rabbit Anti-RANBP3 Monoclonal Antibody (TH239DS) (MOR-4725)
- Species Reactivity: Human
- Type: IgG
- Application: WB, IF, ICC
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For Research Use Only. Not For Clinical Use.

This gene encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. This protein plays a role in nuclear export as part of a heteromeric complex. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Protein class

Cancer-related genes

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Spermatocytes)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Interacts with CHC1 in a Ran-stimulated manner. Interacts with XPO1. Interacts (via its C-terminal R domain) with SMAD2 (dephosphorylated form via its MH1 and MH2 domains); the interaction results in the nuclear export of SMAD2 and termination of the TGF-beta signaling. Interacts (via its C-terminal R domain) with SMAD3 (dephosphorylated form via its MH1 domain); the interaction results in the nuclear export of SMAD3 and termination of the TGF-beta signaling.

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