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SATB1
Anti-SATB1 Recombinant Antibody Products
- Anti-SATB1 Immunohistochemistry Kit (VS-0325-XY2007)
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- Species Reactivity: Human, Mouse, Rat
- Target: SATB1
- Application: IHC
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For Research Use Only. Not For Clinical Use.
This gene encodes a matrix protein which binds nuclear matrix and scaffold-associating DNAs through a unique nuclear architecture. The protein recruits chromatin-remodeling factors in order to regulate chromatin structure and gene expression. [provided by RefSeq, Apr 2016]
Protein class
Plasma proteins, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Inhibitory neurons, Excitatory neurons, Oligodendrocyte precursor cells)
Immune cell specificity
Immune cell enhanced (naive CD4 T-cell)
Cell line specificity
Cell line enhanced (HDLM-2, JURKAT, MOLT-4, REH, THP-1)
Interaction
Interacts with CUX1 (via DNA-binding domains); the interaction inhibits the attachment of both proteins to DNA (By similarity). Homodimer. Part of the nuclear protein complex gamma-globin promoter and enhancer binding factor (gamma-PE) composed at least of SATB1 and HOXB2. Interaction with CtBP1 when not acetylated stabalizes attachment to DNA and promotes transcription repression. Interacts with PCAF. Interacts with sumoylated PML and HDAC1 via the ULD domain. Interacts also with DYNLT3 and POLR2J2. Binds to EP300. (Microbial infection) Interacts (via the ULD domain) with HIV-1 Tat.
Molecular function
Chromatin regulator, DNA-binding, Repressor
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