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SEMA4D
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For Research Use Only. Not For Clinical Use.
Background
SEMA4D (Semaphorin 4D) is a Protein Coding gene. Diseases associated with SEMA4D include Hemorrhagic Fever With Renal Syndrome and Osteonecrosis Of The Jaw. Among its related pathways are Development Slit-Robo signaling and Semaphorin interactions. Gene Ontology (GO) annotations related to this gene include receptor binding and transmembrane signaling receptor activity. An important paralog of this gene is SEMA4C.
Protein class
CD markers, Plasma proteins
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Oligodendrocytes, NK-cells, T-cells, dendritic cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (HDLM-2, HMC-1, JURKAT, MOLT-4)
Interaction
Homodimer (PubMed:20877282). Interacts with PLXNB2 (By similarity). Interacts with PLXNB1 (PubMed:10520995).
Molecular function
Developmental protein, Receptor
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