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  • Afuco™ Anti-Human SEMA4D ADCC Recombinant Antibody (VX15/2503), ADCC Enhanced

Afuco™ Anti-Human SEMA4D ADCC Recombinant Antibody (VX15/2503), ADCC Enhanced (CAT#: AFC-537CL)

Anti-SEMA4D ADCC Enhanced Antibody (VX15/2503) is an ADCC enhanced antibody produced by our Afuco™ platform. VX15/2503 is a novel monoclonal antibody that blocks the activity of SEMA4D. Preclinical testing has demonstrated beneficial effects of anti-SEMA4D treatment in a variety of neurodegenerative disease models. VX15/2503 was well tolerated and no Maximum Tolerated Dose (MTD) was reached.

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Normal Tissue
Figure 1 IHC staining of human skeletal muscle
Figure 1 IHC staining of human skeletal muscle
(Immunohistochemical staining of human skeletal muscle shows strong cytoplasmic positivity in myocytes.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23277/ihc_selected.jpg
Figure 2 Cerebral cortex
Figure 2 Cerebral cortex
(Glial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15662/37983_B_8_5.jpg
Figure 3 Colon
Figure 3 Colon
(Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15662/37983_A_7_3.jpg
Figure 4 Liver
Figure 4 Liver
(Cholangiocytes Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Hepatocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15662/37983_A_7_4.jpg
Figure 5 Kidney
Figure 5 Kidney
(Cells in glomeruli Staining: Low Intensity: Moderate Quantity: <25% Location: nuclear Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15662/37983_A_7_5.jpg
Figure 6 Testis
Figure 6 Testis
(Leydig cells Staining: High Intensity: Strong Quantity:>75% Spermatogonia cells Staining: Medium Intensity: Moderate)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15662/37983_A_6_6.jpg
Figure 7 Lymph node
Figure 7 Lymph node
(Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/15662/37983_A_9_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (HDLM-2, HMC-1, JURKAT, MOLT-4)
Figure 8 RNA cell line category: Cell line enhanced (HDLM-2, HMC-1, JURKAT, MOLT-4)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000187764-SEMA4D

Specifications

  • Host Species
  • Humanized
  • Derivation
  • Humanized
  • Type
  • ADCC enhanced antibody
  • Species Reactivity
  • Human
  • Related Disease
  • Cancer; Multiple Sclerosis; Solid Tumors

Product Property

  • Purity
  • >95% as determined by analysis by RP-HPLC
  • Storage
  • Short term: store at 4°C (over 6 months), long term: -20°C or -80°C.

Target

  • Alternative Names
  • SEMA4D; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D; CD100; SEMAJ; coll-4; C9orf164; M-sema-G; semaphorin-4D; A8; GR3; BB18; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, 4D

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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Humanized Antibody Products IgG Antibody Products Rabbit Monoclonal Antibody Products ScFv Antibody Products Fab Antibody Products Non-Human Primate (NHP) Antibody Products Flow Cytometry (FC) related Products
CAT Product Name Application Type
TAB-559CL Human Anti-SEMA4D Recombinant Antibody (TAB-559CL) ELISA Human IgG
TAB-429CT-S(P) Humanized Anti-SEMA4D Recombinant Antibody; scFv Fragment (TAB-429CT-S(P)) WB, ELISA, FC, BL Humanized scFv
TAB-430CT-S(P) Humanized Anti-SEMA4D Recombinant Antibody; scFv Fragment (TAB-430CT-S(P)) WB, ELISA, FC, BL Humanized scFv
TAB-429CT-F(E) Humanized Anti-SEMA4D Recombinant Antibody; Fab Fragment (TAB-429CT-F(E)) WB, ELISA, FC, BL Humanized Fab
TAB-430CT-F(E) Humanized Anti-SEMA4D Recombinant Antibody; Fab Fragment (TAB-430CT-F(E)) WB, ELISA, FC, BL Humanized Fab

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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