SEPT6

AbPlus Formats

Anti-SEPT6 Recombinant Antibody Products

Recombinant Mouse anti-Human SEPT6 Monoclonal antibody (1D6) (MOB-1437CT)
- Species Reactivity: Human
- Application: ELISA, WB
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For Research Use Only. Not For Clinical Use.

This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]

Protein class

Plasma proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (dendritic cells, Hofbauer cells, Extravillous trophoblasts, Cytotrophoblasts, Syncytiotrophoblasts, Plasma cells, B-cells)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (JURKAT, MOLT-4, REH, SH-SY5Y)

Interaction

Septins polymerize into heterooligomeric protein complexes that form filaments, and associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Filaments are assembled from asymmetrical heterotrimers, composed of SEPTIN2, SEPTIN6 and SEPTIN7 that associate head-to-head to form a hexameric unit. Within the trimer, directly interacts with SEPTIN2 and SEPTIN7. Also interacts with SEPTIN9 and SEPTIN12. Interaction with SEPTIN12 alters filament structure. Component of a septin core octomeric complex consisting of SEPTIN12, SEPTIN7, SEPTIN6 and SEPTIN2 or SEPTIN4 in the order 12-7-6-2-2-6-7-12 or 12-7-6-4-4-6-7-12 and located in the sperm annulus. Interacts with SOCS7. Interacts with HNRNPA1. (Microbial infection) Interacts with HCV NS5B.

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