Plasma proteins
Intracellular, Secreted (different isoforms)
Cell type enhanced (Exocrine glandular cells, Pancreatic endocrine cells, Urothelial cells)
Low immune cell specificity
Cell line enhanced (CAPAN-2, OE19, U-937)
Monomer (PubMed:23269243). Interacts (via C-terminus) with CASP1; CASP4 (via CARD domain) and CASP5; these interactions regulate the activity of inflammatory caspases (PubMed:30692621). Interacts with PRTN3 (PubMed:30692621). Interacts with GZMH (PubMed:23269243).
Protease inhibitor, Serine protease inhibitor
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For Research Use Only. Not For Clinical Use.