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SLC1A2

Anti-SLC1A2 ProductsBackground
Anti-SLC1A2 Products
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: IHC-Fr, IHC-P
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- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: IgG
- Application: WB, IP
- Anti-SLC1A2 Immunohistochemistry Kit (VS-0525-XY6642)
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- Species Reactivity: Human
- Target: SLC1A2
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been identified.
Protein class
Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Transporters
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enriched (Astrocytes)
Immune cell specificity
Immune cell enhanced (basophil)
Cell line specificity
Cell line enhanced (ASC TERT1, BJ hTERT+, fHDF/TERT166, Hep G2, NTERA-2, SCLC-21H)
Interaction
Homotrimer (PubMed:15265858, PubMed:15483603, PubMed:26483543). Isoform 3 can oligomerize with isoform 1 (PubMed:20688910). Interacts with AJUBA (By similarity).
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