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SLC7A5

Anti-SLC7A5 Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


SLC7A5, also known as LAT1 (L - type amino acid transporter 1), is a member of the solute carrier family of membrane - bound transporters. It is a heterodimeric protein that forms a complex with 4F2hc (SLC3A2) to function as an amino acid transporter. Structurally, SLC7A5 has 12 transmembrane domains, and the heterodimeric complex is essential for its proper trafficking to the cell membrane and substrate recognition.
Protein class

Metabolic proteins, Transporters

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Basal squamous epithelial cells, Plasma cells, Microglial cells, Syncytiotrophoblasts)

Immune cell specificity

Immune cell enriched (plasmacytoid DC)

Cell line specificity

Cell line enhanced (HBEC3-KT, hTCEpi, MCF7, SiHa)

Interaction

Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc (PubMed:10049700, 10391915, 10574970, 11311135, 11389679, 11557028, 11564694, 12117417, 12225859, 15769744, 9751058, 25998567, 30867591). Interacts with LAPTM4B; this recruits the heterodimer formed by SLC3A2/4F2hc and SLC7A5 to lysosomes to promote leucine uptake into these organelles and is required for mTORC1 activation (PubMed:25998567).

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