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For Research Use Only. Not For Clinical Use.
Metabolic proteins, Transporters
Membrane
Cell type enhanced (Basal squamous epithelial cells, Plasma cells, Microglial cells, Syncytiotrophoblasts)
Immune cell enriched (plasmacytoid DC)
Cell line enhanced (HBEC3-KT, hTCEpi, MCF7, SiHa)
Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc (PubMed:10049700, 10391915, 10574970, 11311135, 11389679, 11557028, 11564694, 12117417, 12225859, 15769744, 9751058, 25998567, 30867591). Interacts with LAPTM4B; this recruits the heterodimer formed by SLC3A2/4F2hc and SLC7A5 to lysosomes to promote leucine uptake into these organelles and is required for mTORC1 activation (PubMed:25998567).