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SOX8
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the mental retardation found in haemoglobin H-related mental retardation (ART-16 syndrome).
Protein class
Transcription factors
Predicted location
Intracellular
Single cell type specificity
Group enriched (Muller glia cells, Oligodendrocytes, Oligodendrocyte precursor cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (RH-30)
Molecular function
DNA-binding
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