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SPIRE1
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For Research Use Only. Not For Clinical Use.
Background
Spire proteins, such as SPIRE1, are highly conserved between species. They belong to the family of Wiskott-Aldrich homology region-2 (WH2) proteins, which are involved in actin organization (Kerkhoff et al., 2001 [PubMed 11747823]).
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Late spermatids, Early spermatids, Excitatory neurons, Inhibitory neurons, Astrocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (hTERT-HME1, U-2197)
Interaction
Interacts with FMN2.
Molecular function
Actin-binding
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