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STMN3
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a protein which is a member of the stathmin protein family. Members of this protein family form a complex with tubulins at a ratio of 2 tubulins for each stathmin protein. Microtubules require the ordered assembly of alpha- and beta-tubulins, and formation of a complex with stathmin disrupts microtubule formation and function. A pseudogene of this gene is located on chromosome 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Granulosa cells, Horizontal cells, Bipolar cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (AN3-CA, MOLT-4, REH, SCLC-21H, SH-SY5Y)
Interaction
Interacts with STAT3. Interacts with CLU (secreted form); this interaction may act as an important modulator during neuronal differentiation (By similarity).
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